Future of Osteoporosis Genetics: Enhancing Genome-Wide Association Studies

Genome Wide Association Studies, Next Generation Sequencing and Their Application in Animal Breeding and Genetics: A Review

Recently genetic studies have been revolutionized by next generation sequencing (NGS) technology, and it is expected that the use of this technology will largely eliminate defects in the methods of association studies. The NGS technology is becoming the premier tool in genetics. However, at the moment the use of this method is limited especially in the livestock due to high cost and computation...

Genome-wide Association Studies for Osteoporosis: A 2013 Update

In the past few years, the bone field has witnessed great advances in genome-wide association studies (GWASs) of osteoporosis, with a number of promising genes identified. In particular, meta-analysis of GWASs, aimed at increasing the power of studies by combining the results from different study populations, have led to the identification of novel associations that would not otherwise have bee...

Genome-wide association studies: understanding the genetics of common disease

Advances in Genetics Moving Beyond Genome-Wide Association Studies

The sequencing of the human genome1 and the subsequent completion of the human haplotype mapping (HapMap) project2 have led to unparalleled research into the structure and biology of the genome. These milestones held the promise of revolutionizing our understanding of the genetic basis for human disease, with the hope that population research would quickly lead to improved screening and diagnos...

Genome-wide association studies of common obesity: now and future.

Obesity has become a major public health concern worldwide. Obesity is a complex disease influenced by both genetic and environmental factors. Epidemiological studies have indicated that environmental factors, such as excessive energy intake and lack of physical activity, might contribute to the development of obesity. Genetic factors also play an important role in the pathogenesis of obesity. ...